Joachin Frank


               Joachim Frank born 12 September 1940 is a German-born American biophysicist at Columbia UniversityNew York City and a Nobel laureate. He is regarded as the founder of single-particle cryo-electron microscopy  , for which he shared the Nobel Prize in Chemistry in 2017 with Jacques Dubochet and Richard Henderson. He also made contributions to structure and function of the ribosome from bacteria and eukaryotes.



Frank was born in Weidenau After completing his Vordiplom (B.S.) degree in Physics at the University of Freiburg 1963and his Diplom under Walter Rollwagen’s mentorship at the Ludwig Maximilians University of Munich with the thesis “Untersuchung der Sekundärelektronen-Emission von Gold am Schmelzpunkt Investigation of secondary electron emission of gold at its melting point 1967, Frank obtained his Ph.D. from the Technical University of Munich for graduate studies in Walter Hoppe’s lab at the Max Planck Institut für Eiweiss- und Lederforschung now Max-Planck-Institut für Biochemie with the dissertation Investigations of high-resolution electron micrographs using image difference and reconstruction methods 1970. The thesis explores the use of digital image processing and optical diffraction in the analysis of electron micrographs, and alignment of images using the cross-correlation function.

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